Art can certainly make a large impact in a room. Here multiple contemporary art pieces are used in this traditionally furnished dining room.
Symmetrically hung artwork makes an impact as in this example of artwork in an entry way.
This really caught my eye- I love the coloring, but also love that the sofa is arranged under the artwork rather than the usual way - with the artwork balanced within the width of the sofa.
And last but not least-- One large impacting piece of art used in a small area.
photos: 1-3 Chicago Home & Garden
photo: 4 Jagminbros's Blog